We're down to the final week of the 2025 regular season. Playoff teams are figuring out whether to play their starters or go with backups to avoid key injuries. So, what's the motivation for clubs eliminated from postseason contention?

For Week 18 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 18 NFL schedule here. After analyzing every game in Week 18, the AI says the Rams (-7.5, 46.5), who have already clinched a postseason berth, cover comfortably against the Cardinals.

Only two playoff spots are still up for grabs, but playoff seeding is still at stake for most of the teams in the playoff picture.

This is it, football fan! The final week of the 2025-26 NFL regular season has arrived. Two games will take place on Saturday, another 14 will be played on Sunday, and that two-day stretch will put the finishing touches on this year's playoff field.

The Detroit Lions will look to close out their season with a win against the Chicago Bears on Sunday. The Bears have already clinched an NFC North championship.

Picking the Ravens over the Steelers is almost too easy. We also like the Seahawks over the 49ers and Bucs over Panthers in critical games.

The Seahawks will play their most important game of the season in Week 18. Here are 3 Seahawks bold predictions against the 49ers.